Enroll in the Hub to access THIOLA® (tiopronin) tablets

For some people with cystinuria, making therapeutic lifestyle changes such as drinking more water, reducing your protein and sodium intake, and adjusting the pH of your urine may not be enough to stop cystine stones from forming. If you or your loved one is still forming cystine stones, THIOLA can help.

Getting THIOLA is simple. Download and complete the THIOLA Total Care Hub enrollment form to get started today.

For any questions or help with the enrollment forms, call 844-4-THIOLA (844-484-4652).


Gain access to Hub services

Let the Total Care Hub streamline the insurance verification and approval process. Joining gives you access to Hub services and makes receiving THIOLA easy and convenient.

Hub Counselor

Hub Counselor

A dedicated Hub Counselor will work with insurance companies to assist with benefit verification, prior authorizations, and appeals.



The Total Care Hub will partner with physicians and staff to help organize relevant documentation throughout treatment.

Maintaining therapy

Maintaining therapy

We ensure your therapy is not interrupted during changes in marital, employment, or disability status that may affect insurance coverage.

Financial assistance

Financial assistance

We provide co-pay assistance,a reimbursement, and patient assistance programs for those who are eligible.

aPertains to commercial insurance.

Download and complete the THIOLA Total Care Hub enrollment form today.


Convenient delivery for optimal disease management

Adherence can be easy with the help of the Delivery Hub:

  • THIOLA prescriptions will be delivered directly to patients, saving trips to the pharmacy
  • THIOLA can be delivered in a convenient monthly care packet
  • Individuals can plan ahead and manage refills so that a dose is never missed
  • Prescheduled refill delivery is available for those who are eligible

Live, on-demand support at any time

Available 24 hours a day, 7 days a week, a Hub representative can:


Answer questions about treatment


Set up refills and appointment reminders


Connect you with a Hub pharmacist to answer questions about THIOLA


Call 844-4-THIOLA (844-484-4652)

The Support Hub is available 24 hours a day, 7 days a week.


THIOLA® (tiopronin) tablets are a prescription medicine used to help prevent the formation of cystine (kidney) stones in patients who were not successfully treated with dietary changes and increased fluid intake, or patients who have had side effects with the drug d-penicillamine.

Important Safety Information 

THIOLA is not for everyone. You should not take THIOLA if you:

  • Are pregnant or plan to become pregnant
  • Are breastfeeding or plan to breastfeed
  • Have a history of blood disorders including aplastic anemia (your bone marrow does not make enough new cells), agranulocytosis (decrease in certain white blood cells), or thrombocytopenia (decrease in the number of platelets)

The safety and effectiveness of THIOLA have not been established in children under 9 years of age, and there are no well-controlled studies in pregnant women. High doses of THIOLA in pregnant laboratory animals have been shown to harm the fetus, so you should talk about these risks with your doctor to determine whether THIOLA is right for you. No long-term animal studies have been performed to see whether THIOLA can cause cancer, so you should discuss these risks with your doctor.

While you are taking THIOLA, your doctor will monitor you closely for signs and symptoms of possible complications. Your doctor will routinely do certain blood and urine tests, and yearly scans of your abdomen to look at the size and appearance of kidney stones. THIOLA should only be used under the close supervision of your doctor.

THIOLA can cause serious side effects or potential complications, and some of these could be fatal. Therefore, it is important to call your doctor right away if you have any side effects.

Side effects associated with THIOLA include a drug-related fever that typically occurs during the first month of treatment. If this occurs, talk with your doctor, who may discontinue treatment until the fever goes away. 

You may notice a reduced sense of taste while taking THIOLA, which will eventually go away. Some patients also report wrinkling or thin, fragile skin during long-term treatment.

Other side effects of THIOLA may include an itchy rash that is found on many parts of your body. This typically occurs during the first few months of treatment, and antihistamines can help reduce the itching. The rash will usually disappear once you stop taking THIOLA. Less often, patients who take THIOLA for more than 6 months may develop a rash that is usually located on the upper body and is very itchy. It typically goes away slowly after discontinuing treatment and returns after re-starting treatment.

Some patients may develop a drug hypersensitivity reaction to THIOLA that includes fever, joint pain, and swollen lymph nodes. If this occurs, your doctor may discontinue THIOLA.

THIOLA can cause serious and potentially fatal blood disorders, including aplastic anemia (your bone marrow does not make enough new cells), agranulocytosis (decrease in certain white blood cells), or thrombocytopenia (decrease in the number of platelets). Call your doctor immediately if you have any signs or symptoms such as fever, sore throat, chills, bleeding, or if you are bruising more easily.

Although THIOLA may be less toxic than d-penicillamine, it could potentially cause all of the serious side effects reported for d-penicillamine. No deaths have been reported as a result of THIOLA treatment; however, fatal outcomes have been reported with certain complications of d-penicillamine therapy, including reduced white blood cells, red blood cells, or platelets; Goodpasture's syndrome (an autoimmune disorder that affects the lungs and kidneys); and myasthenia gravis (an autoimmune disorder that causes muscles to weaken). Do not take THIOLA if you have a history of these conditions.

Additional side effects that have been reported during treatment with d-penicillamine and that might occur during THIOLA treatment include:  decreased sense of smell, nausea, vomiting, diarrhea or soft stools, loss of appetite, abdominal pain, bloating, gas, sore throat, sores in the mouth, hives, warts, swelling of the throat, difficulty breathing, shortness of breath, fatigue or weakness, muscle or joint pain, swelling in your legs or fluid build-up in the lungs, lung or kidney problems, and blood or high amounts of protein in urine. These side effects are more likely to develop during THIOLA therapy in patients who had previous reactions to d-penicillamine. Talk to your doctor about any unusual side effects.

Seek immediate medical attention and discontinue THIOLA if you notice symptoms such as fever, sore throat, chills, bleeding, easy bruising, coughing up blood, muscle weakness, blistering or raw areas on the skin or mucous membranes, joint pain, swelling of the lymph nodes, or swelling in your legs, as these may be signs of a serious reaction to the drug.

Jaundice (yellow appearance of the skin and whites of the eyes) and abnormal liver function tests have been reported during THIOLA treatment for conditions unrelated to cystine stones.

Call your doctor for medical advice about side effects. You may report negative side effects to Retrophin® Medical Information at 1-877-659-5518, or to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please see full Prescribing Information.