Why should you consider THIOLA?

For some people with cystinuria, making therapeutic lifestyle changes such as drinking more water and reducing your protein and sodium intake may not be enough to stop cystine stones from forming. If you or your loved one is still forming cystine stones, THIOLA can help. See Important Safety Information below.

Download the enrollment form and talk to your doctor about how the right dose of THIOLA, in conjunction with making healthy lifestyle choices, can help you become—and stay—stone-free.

How does THIOLA work?

THIOLA reduces the risk of stone formation by lowering the amount of cystine in your urine.

Picture of excess cystine

In people living with cystinuria, cystine does not get reabsorbed from the urine properly. This leads to an increase of cystine in the urine. When there’s too much cystine in the urine (what doctors call above the solubility limit—more than 250 mg of cystine per liter of urine), cystine stones form.

Picture of THIOLA binding to excess cystine

THIOLA combines with cystine in the urine, allowing cystine to dissolve more easily. This lowers the amount of cystine in the urine, which reduces the risk of cystine kidney stone formation. 

Attention

Do you know your cystine level?

Don’t let your cystine level control you. Keep your urinary cystine level in check—talk to your doctor about 24-hour urine collection.

Is THIOLA right for you?

Talk to your doctor about THIOLA if

  • You are still forming stones with your current treatment plan  
  • Your cystine level is above the line of solubility (>250 mg/L)

THIOLA is an adjunctive therapy to diet modification, urinary alkalinization, and high fluid intake, or for those who have adverse reactions to
d-penicillamine.

Taking THIOLA can be an effective way to control your cystinuria

Living with cystinuria can be a challenge. Fortunately, THIOLA can help reduce stone burden. Imagine what your life could be like if you were stone-free.

A clinical trial showed that THIOLA stopped stones from forming completely or reduced the rate of stone formation, in the majority of study participants, regardless of whether participants had already taken d-penicillamine. 

The table shows the trial results in greater detail. 

Efficacy results in people treated with THIOLA

  Study group previously treated with d-penicillamine (43 participants)

Study group not previously treated with d-penicillamine (14 participants)

Rate of stone reduction

81.4%

94.1%

Rate of stone prevention

62.8%

71.4%

 

THIOLA can be an important part of treatment by either reducing or stopping stones from forming whether or not people with cystinuria have taken d-penicillamine.

Effective treatment

Effective treatment on THIOLA relies on finding an optimal dose and adhering to healthy lifestyle choices. Work with your doctor to find the THIOLA dose that’s right for you.

Optimal management relies on

  • Starting on the right dose for you
  • Monitoring your cystine levels through 24-hour urine collection to determine necessary dosing adjustments
  • Telling your doctor about any reactions you may have to THIOLA

THIOLA is associated with fewer or less severe adverse reactions than d-penicillamine.  Despite this apparent reduced toxicity to THIOLA relative to d-penicillamine, THIOLA treatment may potentially be associated with all the adverse reactions reported with d-penicillamine.

See Important Safety Information below.

THIOLA® (tiopronin)

Important Safety Information

What is THIOLA® (tiopronin) tablets?

THIOLA tablets is a prescription medicine.  It is used in combination with high fluid intake, alkali (low acid), and dietary changes to help prevent the formation of one type (cystine) of kidney stones in certain adult and pediatric patients that weigh at least 44 pounds (20 kg) and who do not respond to these measures alone. 

Who should not take THIOLA?

THIOLA should not be taken if you:

  • Are allergic to THIOLA, or any of the ingredients in THIOLA.

What should I tell my doctor before taking THIOLA?

THIOLA may not be right for you.  Before taking THIOLA, tell your doctor about:

  • all health conditions you may have and any medications you may be taking
  • if you are pregnant or plan to become pregnant
  • if you are breastfeeding or plan to breastfeed

What are possible side effects of THIOLA?

Serious Side Effects: THIOLA can cause proteinuria (high amounts of protein in urine), including serious kidney problems, and hypersensitivity reactions (including fever, rash, joint pain and enlarged or swollen lymph nodes).

Most Common Side Effects: Nausea, diarrhea or soft stools, sores in the mouth, rash, fatigue, fever, muscle or joint pain, high amounts of protein in urine, vomiting.

These are not all the possible side effects of THIOLA. Call your doctor for medical advice about side effects.

You may report negative side effects to Retrophin® Medical Information at 1-877-659-5518, or to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch

Please see full THIOLA Prescribing Information

 

THIOLA® EC (tiopronin)

Important Safety Information

What is THIOLA® EC (tiopronin) delayed-release tablets?

THIOLA EC delayed-release tablets is a prescription medicine.  It is used in combination with high fluid intake, alkali (low acid), and dietary changes to help prevent the formation of one type (cystine) of kidney stones in certain adult and pediatric patients that weigh at least 44 pounds (20 kg) and who do not respond to these measures alone. 

Who should not take THIOLA EC?

THIOLA EC should not be taken if you:

  • Are allergic to THIOLA EC, or any of the ingredients in THIOLA EC.

What should I tell my doctor before taking THIOLA EC?

THIOLA EC may not be right for you.  Before taking THIOLA EC, tell your doctor about:

  • all health conditions you may have and any medications you may be taking
  • if you are pregnant or plan to become pregnant
  • if you are breastfeeding or plan to breastfeed

What should I avoid while taking THIOLA EC?

You should avoid drinking alcohol 2 hours before and 3 hours after taking THIOLA EC.

What are possible side effects of THIOLA EC?

Serious Side Effects: THIOLA EC can cause proteinuria (high amounts of protein in urine), including serious kidney problems, and hypersensitivity reactions (including fever, rash, joint pain and enlarged or swollen lymph nodes).

Most Common Side Effects: Nausea, diarrhea or soft stools, sores in the mouth, rash, fatigue, fever, muscle or joint pain, high amounts of protein in urine, vomiting.

These are not all the possible side effects of THIOLA EC. Call your doctor for medical advice about side effects.

You may report negative side effects to Retrophin® Medical Information at 1-877-659-5518, or to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.  

Please see full THIOLA EC Prescribing Information